Synthesis and cytotoxic activity of N-(4-bromo)-benzoyl-N’phenylthiourea and 4-(tert-butyl)-N-benzoylurea on primary cells of HER2-Positive breast cancer
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چکیده
منابع مشابه
tert-Butyl N-{4-[N-(4-hydroxyphenyl)carbamoyl]benzyl}carbamate
In the title compound, C(19)H(22)N(2)O(4), the dihedral angle between the aromatic rings is 67.33 (2)°. In the crystal, mol-ecules are linked through N-H⋯O and O-H⋯O hydrogen bonds, generating a two-dimensional network lying parallel to (100). As a result of the twist of the mol-ecular skeleton and the hindrance of the tert-butyl groups, no π-π inter-actions exist between the aromatic rings.
متن کاملtert-Butyl N-benzyl-N-(4-methyl-2-pyridyl)carbamate
In the crystal structure of the title compound, C(18)H(22)N(2)O(2), the pyridine ring makes dihedral angles of 83.71 (6) and 9.2 (1)° with the phenyl ring and the carbamate plane, respectively. The phenyl ring and the carbamate plane are nearly perpendicular to one another, with a dihedral angle of 87.17 (7)°.
متن کاملtert-Butyl N-[2-(N-isobutyl-4-methoxybenzenesulfonamido)ethyl]carbamate
The title compound, C18H30N2O5S, was synthesized by the reaction of tert-butyl 2-(iso-butyl-amino)-ethyl-carbamate with p-meth-oxy-phenyl-sulfonyl chloride. In the mol-ecule, two intra-molecular C-H⋯O hydrogen bonds are observed. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds involving the imino group N atom and the ester group O atom into chains running parallel to the b axis. T...
متن کاملN-Benzoyl-4-methylbenzenesulfonamide
In the title compound, C(14)H(13)NO(3)S, the N-H bond in is anti to the C=O bond. The dihedral angle between the two aromatic rings is 79.4 (1)°. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds, generating C(4) chains.
متن کاملN-Benzoyl-4-chlorobenzenesulfonamide
The asymmetric unit of the title compound, C(13)H(10)ClNO(3)S, contains two independent mol-ecules. The mol-ecules have C-S-N-C torsion angles of -70.0 (2) and 61.3 (2)° for mol-ecules 1 and 2, respectively. The dihedral angles between the sulfonyl benzene rings and the -SO(2)-NH-C-O segments are 72.0 (1) and 77.3 (1)° for mol-ecules 1 and 2, respectively, and the dihedral angles between the su...
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ژورنال
عنوان ژورنال: RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
سال: 2021
ISSN: 0974-3618,0974-360X
DOI: 10.5958/0974-360x.2021.00213.4